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Imagine all the cells in your body as a locked door. In order to open the door you need a key. Insulin is that key. It binds to the cells and allows the transport of calories and nutrients into the cells. Now depending on the food consumed or the glycemic index rating of that food, the insulin will either be a very fast abundant release or a slow and steady release.
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For studies with more than one follow up data point during this interval, we chose the one closest to 12 months. A risk ratio was estimated for most of the studies that compared an intervention group with a usual care or control group. For the few studies that contained more than one intervention group, we estimated multiple risk ratios, one for each intervention compared with the common usual care or control group, and performed a sensitivity analysis to assess the impact of correlation among these ratios.
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